The Impact of Hemodiafiltration Versus Hemodialysis on Uremic Symptoms, Physical Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

ABSTRACT:

Rationale & objective

Uremic symptoms and frailty in kidney failure may be driven by the accumulation of uremic toxins that are variably cleared by dialysis. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated the effect of hemodiafiltration (HDF) compared to hemodialysis (HD) on uremic symptoms, physical function, and quality of life (QOL).

Study design

Systematic review and meta-analysis.

Setting & study populations

We searched Medline, EMBASE, Cochrane Library, CINAHL, and PROSPERO up to September 2024 for RCTs comparing maintenance HDF vs HD in adults with kidney failure.

Selection criteria

RCTs with the following outcomes: uremic symptoms as measured by patient-reported outcome measures (PROMs), physical

SUBMITTER: Sanchez YP 

PROVIDER: S-EPMC12598937 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature