Proteins upregulated in thrombotic antiphospholipid syndrome linked to platelet function in contrast with non-antiphospholipid-related thrombosis: insights from two systematic reviews.

ABSTRACT:

Background

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by thrombosis, pregnancy complications and other non-thrombotic manifestations in the presence of antiphospholipid antibodies (aPL). Since its identification in 1983, research on APS has progressed, but no targeted therapies other than anticoagulation are yet available, with a mortality rate of 9.3% after a 10-year follow-up.

Objective

The aim of the current systematic literature reviews (SLRs) is to identify and compare upregulated proteins in patients with thrombotic APS (tAPS) and non-aPL thrombosis, thereby providing useful insights into APS pathogenesis.

Methods

We conducted two SLRs in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses gu

SUBMITTER: Mancuso S 

PROVIDER: S-EPMC12598954 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature