Pursuing Reduction in Fatigue After COVID-19 via Exercise and Rehabilitation (PREFACER): a protocol for a randomised feasibility trial.

ABSTRACT:

Introduction

Over 777 million COVID-19 infections have occurred globally, with data suggesting that 10%-20% of those infected develop Long COVID. Fatigue is one of the most common and disabling symptoms of Long COVID. We aim to assess the feasibility and safety of a new, remotely delivered, multimodal rehabilitation intervention, paced to prevent post-exertional malaise (PEM), to support the conduct of a future, definitive randomised trial.

Methods and analysis

We will conduct a randomised, two-arm feasibility trial (COVIDEx intervention vs usual care). Sixty participants with Long COVID will be recruited and randomised prior to giving informed consent under a modified Zelen design using 1:1 allocation with random permuted blocks via central randomisation to receive either t

SUBMITTER: Billias N 

PROVIDER: S-EPMC12598962 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature