Shugan Xiaozhi Decoction attenuates nonalcoholic steatohepatitis by modulating oxidative stress and AMPK pathway.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD), particularly the histological phenotype nonalcoholic steatohepatitis (NASH), is considered the primary cause of chronic liver diseases. Shugan Xiaozhi decoction (SX), a composite Chinese medicinal formula, has shown therapeutic potential for NASH, although the underlying mechanisms remain incompletely defined. In this study, the effects and mechanisms of SX in rats with NASH and fibrosis induced by a high-fat and high-cholesterol (HFHC) diet were investigated.

Methods

NASH rats with fibrosis were induced by an HFHC diet, with different doses of SX administered. Biochemical indices, histological changes, and gene expression were assessed to evaluate lipid metabolism, inflammation, fibrosis of the liver. The histological cha

SUBMITTER: Yang R 

PROVIDER: S-EPMC12599033 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature