Transcriptomics-based analysis of acetate and propionate transport and metabolism in Yarrowia lipolytica.

ABSTRACT:

Background

Yarrowia lipolytica is a promising host for sustainable microbial oil production from waste-derived carboxylic acids such as acetate and propionate. Nonetheless, the molecular mechanisms underlying the metabolism and assimilation of these substrates, particularly under nitrogen limitation, are still not fully understood.

Results

We conducted a multi-condition transcriptomic analysis of Y. lipolytica strain EXF-17398 under nitrogen-limiting conditions to investigate its transcriptional adaptation to acetate and propionate utilisation. Our results revealed distinct transcriptional responses associated with metabolic adaptation, including the coordinated regulation of Jen and Gpr carboxylate transporter families, suggesting a dual system for carboxylate uptake. JEN5

SUBMITTER: Zganjar M 

PROVIDER: S-EPMC12599084 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature