Multi-omics and machine learning identify GBP2 as a key therapeutic target of Qingre Kasen granules in lupus nephritis via NF-kappaB modulation.

ABSTRACT: Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammatory and immune system diseases. This study aimed to identify LN biomarkers and mechanisms via systems biology approach, and multi-omics integration, and to screen potential active ingredients of QS for the treatment of LN. First, bioinformatics and machine learning were used to screen five genes, namely CHI3L1, CX3CR1, GBP2, CCND1, and PKP4, as well as the NF-kappaB signaling pathway. An external dataset was then employed to confirm that GBP2 plays a crucial role in the pathogenesis of LN. Immune infiltration analysis revealed significant

SUBMITTER: Zhu K 

PROVIDER: S-EPMC12599154 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature