T cell knockout attenuates HFD-induced increases in blood pressure in female and male Dahl rats.

ABSTRACT: Increased body weight is associated with a higher incidence of hypertension in humans. Pre-clinical evidence shows that a high-fat diet (HFD) promotes hypertension. While T cells have been implicated in hypertension, the contribution of T cells to HFD-induced increases in blood pressure (BP) remains unknown. We tested the hypothesis that T cells mediate HFD-induced increases in BP in female and male Dahl rats. Female and male wildtype (WT) Dahl rats were randomized to a normal-fat diet (0.16% kcal from fat) or HFD (59% kcal from fat) from 5 to 15 weeks of age. Aortic and renal T cells were measured by flow cytometry. Additional female and male WT and CD247 (CD3ζ-chain) knockout (KO) Dahl rats were placed on a HFD from 5 to 15 weeks of age. Body weight and fat and lean mass were measured th

SUBMITTER: Ramirez LA 

PROVIDER: S-EPMC12599257 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature