Hollow-core polydopamine nanocarriers for ultrasound-enhanced drug delivery.

ABSTRACT: On-demand drug release is one of the main challenges in nanocarrier design and a key step toward enhancing the efficacy of novel therapeutic formulations. Compared to conventional methods such as pH- or light-driven release, ultrasound-guided drug release offers a cost-effective strategy with improved tissue penetration making it particularly suitable for applications in hard-to-access tissues such as the pancreas. In this study, hollow nanoparticles (hPDA) were developed and evaluated for ultrasound-enhanced drug delivery, focusing on pancreatic ductal adenocarcinoma (PDAC). The hPDA nanoparticles, prepared employing non-toxic reagents, measured approximately 120 nm and were successfully loaded with SN-38, a potent yet challenging-to-formulate chemotherapeutic agent. Ultrasound-triggered

SUBMITTER: Lingamgunta S 

PROVIDER: S-EPMC12599296 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature