Inhibition of BTK and SYK attenuates <i>Porphyromonas gingivalis</i> -induced activation of the pyroptosis pathway and inflammation in host cells.

ABSTRACT:

Background

Periodontitisis a chronic inflammatory disease of the oral cavity, primarily driven by periodontopathogens such as Porphyromonas gingivalis (Pg)."

Objective

We investigated the therapeutic potential of BTK and SYK inhibitors on the pathological processes induced by two Pg strains, ATCC 33277 and W83, in human monocyte-derived macrophages (hMDMs) and human gingival fibroblasts (hGFs).

Design

hMDM and hGF were infected with Pg strains and assessed for viability, inflammatory activation, and phenotype, with or without the BTK inhibitor ibrutinib or SYK inhibitor R406, under acute and chronic infection conditions.

Results

Ibrutinib and R406 suppressed Pg infection-induced activation of the NLRP3-dependent pyroptosis pathway an

SUBMITTER: Plonczynska A 

PROVIDER: S-EPMC12599364 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature