Factors Predicting Additional Residual Nodal Disease With a Metastatic Sentinel Node Biopsy or Targeted Axillary Dissection After Neoadjuvant Chemotherapy.

ABSTRACT:

Purpose

This study aimed to investigate whether specific clinicopathological characteristics are associated with a lower likelihood of additional positive nodes (APNs) on completion axillary lymph node dissection (cALND).

Methods

A total of 497 patients with cT1-4/N1-3 disease underwent cALND following a positive sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC). The APN rate was assessed based on findings from the cALND.

Results

The median age was 47 (21-84). The overall APN rate was 67.6%. Patients with cT1-2 disease, a breast pathological complete response, removal of > two nodes via SLNB or TAD, only one metastatic node identified at SLNB or TAD, a lymph node ratio (LNR) < 50%, or low-volume metastatic dis

SUBMITTER: Cabıoglu N 

PROVIDER: S-EPMC12599433 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature