Safety and efficacy of maternal RSV vaccination: a systematic review and meta-analysis.

ABSTRACT: Respiratory syncytial virus (RSV) maternal vaccination has emerged as a preventive strategy to confer passive immunity to newborn during their early vulnerable months of life. In this review, we aim to assess the efficacy and safety of maternal RSV vaccines. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines for systematic reviews and meta-analyses. Our literature search covered MEDLINE via PubMed, Scopus, Web of Science, and Cochrane. We included randomized controlled trial (RCTs) that assessed the safety and efficacy of maternal RSV vaccines. The overall effect estimates for efficacy outcomes, including RSV-associated lower respiratory tract infection (LRTI), severe LRTI, and hospitalizations, demonstrated statistically significant ben

SUBMITTER: Farag A 

PROVIDER: S-EPMC12599435 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature