Evaluating diagnostic performance of urinary biomarkers in the surveillance of non-muscle invasive bladder carcinoma: A systematic review.

ABSTRACT:

Purpose

Urinary biomarkers have been proposed to play an integral role in detecting recurrent non-muscle invasive bladder carcinoma (NMIBC). This review delineates the diagnostic accuracy of such biomarkers and management strategies in the event of discordance between biomarker findings and flexible cystoscopy, the current gold standard for NMIBC surveillance.

Materials and methods

In accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement, literature searches were conducted across PubMed, Embase, Scopus, and CENTRAL (Cochrane Central Register of Controlled Trials), focusing on studies comparing urinary biomarkers to cystoscopy. The inclusion criteria were based on the PICOS (Patient Intervention Comparison Outcome Study type

SUBMITTER: Ramasamy RP 

PROVIDER: S-EPMC12599468 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature