Succinic Acid Production by Engineered Mannheimia succiniciproducens and Its Use in Chemoenzymatic Poly(Butylene Succinate) Synthesis.

ABSTRACT: Amid growing concerns about climate change, environmental pollution, and fossil resource depletion, bio-based chemicals and materials have garnered significant attention. Succinic acid (SA), a four-carbon dicarboxylic acid, is a key platform chemical for producing industrially important compounds such as poly(butylene succinate) (PBS), a biodegradable polymer. In this paper, we demonstrate the enhanced production of SA using metabolically engineered Mannheimia succiniciproducens PALK (pMS3-gltA) strain, which achieves high SA yields through enhanced biomass production and optimized metabolic pathways. High-purity SA, purified from the fermentation broth, was used in an environmentally friendly two-step polymerization process under mild conditions. In the first step, diethyl succinate was s

SUBMITTER: Kim JY 

PROVIDER: S-EPMC12599488 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature