Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis.

ABSTRACT:

Purpose

Age-related eye diseases (AREDs) are major causes of vision loss worldwide. Biological age acceleration (BAA) reflects systemic aging, but its relationship with AREDs and underlying genetic mechanisms remains unclear. This study investigated the combined effects of BAA and genetic risk on AREDs and blindness, and explored shared genetic pathways and potential anti-aging targets.

Methods

Biological age was measured using the Klemera-Doubal method for estimating biological age (KDM-BA) and PhenoAge algorithms. We assessed the cross-sectional and prospective associations between BAA and AREDs in 297,375 participants from the UK Biobank, followed by genetic pleiotropy analysis.

Results

Participants with higher BAA were more likely to experience AREDs at baseline a

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12599516 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature