A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex.

ABSTRACT: Sensory experience drives the maturation of neural circuits during postnatal brain development through molecular mechanisms that remain to be fully elucidated. One likely mechanism involves the sensory-dependent expression of genes that encode direct mediators of circuit remodeling within developing cells. To identify potential drivers of sensory-dependent synaptic development, we generated a single-nucleus RNA sequencing dataset describing the transcriptional responses of cells in the mouse visual cortex to sensory deprivation or to stimulation during a developmental window when visual input is necessary for circuit refinement. We sequenced 118,529 nuclei across 16 neuronal and non-neuronal cell types isolated from control, sensory deprived and sensory stimulated mice, identifying 1268 se

SUBMITTER: Xavier AM 

PROVIDER: S-EPMC12599534 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature