<i>Saccharomyces boulardii</i> CNCM I-745 mitigates antibiotic-induced gut microbiome functional alterations independently of the host.

ABSTRACT: The probiotic Saccharomyces boulardii CNCM I-745 (Sb) is widely prescribed to alleviate antibiotic-induced diarrhea, yet its mode of action, particularly its potential direct effects on the gut microbiome, remains incompletely defined. This study aimed to evaluate whether Sb can directly mitigate antibiotic-induced gut microbiota dysbiosis and influence downstream host immune response. Using both static (MiPro) and dynamic (SHIME^®) in vitro gut microbiota models, we assessed the effects of Sb supplementation under antibiotic treatment with amoxicillin/clavulanic acid (AMC) or vancomycin (Van). Quantitative microbiome profiling integrated with targeted metabolomics showed that Sb helped stabilize bacterial biomass, partially preserved metabolic functions, and restor

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12599567 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature