Test-Retest Reliability of Perception Threshold Estimation in Small Cutaneous Nerve Fibers: A Methodological Investigation.

ABSTRACT:

Introduction/aims

Nerve excitability testing of small cutaneous nerve fibers has been proposed as a new tool for investigating the underlying mechanisms of small fiber neuropathy. These assessments may be performed using perception threshold tracking with pin-electrodes that preferentially activate small cutaneous nerve fibers. In this study, the test-retest reliability of two perception threshold (PT) algorithms: the Psi method and the Method of Limits (MoL), was compared.

Method

Twenty healthy subjects completed the study. Electrical stimulation was applied using a pin electrode, and the PT to a 1 ms rectangular pulse was estimated six times during two sessions separated by 1 week. The test-retest reliability was evaluated by the intraclass correlation coefficient (ICC) an

SUBMITTER: Brockner H 

PROVIDER: S-EPMC12599603 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature