Role of different anti-seizure medications on carotid intima-media thickness: A systematic review and meta-analysis.

ABSTRACT:

Background

Various types of anti-seizure medication (ASMs) may have an impact on the cardiac health of patients who have epilepsy. One of the most important noninvasive predictive factors related to cardiovascular disease is carotid intima-media thickness (CIMT). The objective of this systematic review and meta-analysis is to determine the effect of both mono- and poly-therapy with ASMs on CIMT.

Methods

Four databases (PubMed, Scopus, Web of Science, and Embase) were searched for records. Studies that measured the effect of ASMs on CIMT were eligible to be included. The case and control data of studies were extracted. Also, the quality assessment of each included study was assessed by the risk of bias in non-randomized studies of interventions (ROBINS-I) checklist. Additiona

SUBMITTER: Davari A 

PROVIDER: S-EPMC12599644 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature