Causal relationship between sarcopenia and cognitive performance: A bidirectional Mendelian randomization study.

ABSTRACT: With the acceleration of global population aging, sarcopenia (SA) and cognitive impairment have become major public health concerns. Observational studies suggest associations between them, but such findings may be biased by confounding and reverse causation. Previous Mendelian randomization (MR) studies have yielded inconsistent results. Therefore, this study applied a bidirectional MR design to clarify their causal relationships. We obtained genetic instrumental variables for SA-related traits, including hand grip strength, lean mass, and usual walking pace, from the UK Biobank. Data on cognitive performance were derived from a large genome-wide association studies meta-analysis published in Nature Genetics in 2018 (n = 257,841), with replication performed in an independent cohort from t

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12599665 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature