Causal associations between sleep disorders and endometriosis: A Mendelian randomization analysis.

ABSTRACT: Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) approach to investigate the causal associations between sleep disorders and endometriosis. We conducted bidirectional 2-sample MR using inverse variance weighting as the primary analysis to assess forward and reverse causality. Multivariable Mendelian randomization were also utilized to adjust for confounders, reducing pleiotropy and residual confounding. Univariable MR analysis demonstrated a positive causal effect of insomnia on endometriosis (inverse variance weighting odds ratio: 2.021, 95% confidence interval: 1.280-3.192, P = .003). Multivariable Mendelian randomization analysis further confirmed that the robu

SUBMITTER: Yang X 

PROVIDER: S-EPMC12599677 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature