Causal relationship between stable angina and bone mineral density: A two-sample bidirectional Mendelian randomization study.

ABSTRACT: This study assesses the causal relationship between bone mineral density (BMD) and stable angina pectoris (SAP) using Mendelian randomization analysis. We obtained genome-wide association study databases for stable angina and BMD, and conducted Mendelian randomization analysis with BMD as the exposure factor and SAP as the outcome. The inverse variance weighted (IVW) method was used as the primary analytical approach, complemented by Cochran Q test, the weighted median method, MR-Egger regression, and the simple weighted model to evaluate the robustness and reliability of the results. The IVW results revealed a significant positive correlation between BMD and the incidence of SAP. When BMD was considered as the exposure factor, the analysis indicated an increased risk of SAP with higher BM

SUBMITTER: Song Y 

PROVIDER: S-EPMC12599691 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature