Computational identification of ECT2 as a potential pan-cancer biomarker and therapeutic target through integrated genomic data analysis.

ABSTRACT: The ECT2 gene, encoding a guanine nucleotide exchange factor, plays crucial roles in cell cycle progression and cytoskeletal dynamics, implicating its involvement in various cancers. However, a comprehensive pan-cancer analysis integrating genomic data is still lacking. This study employed an integrated approach using data from multiple cancer genomics databases to assess ECT2 across various malignancies. Expression profiles of ECT2 were analyzed for differential expression across tumor stages and its association with clinical outcomes. Correlation analyses examined the relationship between ECT2 expression and immune cell infiltration levels. Pathway enrichment analysis identified biological processes influenced by ECT2 dysregulation in cancer progression. These methods facilitated a compr

SUBMITTER: Chen M 

PROVIDER: S-EPMC12599706 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature