Education as a protective factor against lung cancer: A comprehensive Mendelian randomization analysis.

ABSTRACT: Lung cancer remains a leading cause of global morbidity and mortality, imposing a significant healthcare burden worldwide. To comprehensively investigate potential risk factors for lung cancer and provide a theoretical basis for its prevention and treatment, we utilized publicly available genome-wide association study data of European ancestry. We treated various traits as exposures and lung cancer as the outcome. Causal relationships were assessed using 5 Mendelian randomization (MR) methods: inverse-variance weighted, constrained maximum likelihood and model averaging, debiased inverse-variance weighted, contamination mixture, and Mendelian randomization-robust adjusted profile score. We subsequently performed meta-analysis and median-based MR to synthesize the roles of different risk fa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12599716 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature