Association between frailty and gout in middle-aged and older adults: A nationwide cross-sectional and Mendelian randomization study.

ABSTRACT: With the aging population, frailty is becoming increasingly prevalent among older adults, yet its association with gout, a common form of arthritis affecting middle-aged and older adults, remains unclear. This study investigated the frailty-gout relationship through a nationwide cross-sectional analysis combined with Mendelian randomization (MR). Data from 22,324 adults aged 40 and above in the National Health and Nutrition Examination Survey (NHANES, 2007-2018) were analyzed utilizing survey-weighted logistic regression models. Genome-wide association study data from UK Biobank, TwinGen, and FinnGen were utilized to explore genetic correlations and causality. The cross-sectional study indicated a significant relationship between pre-frail (odds ratio [OR] = 2.33, 95% confidence interval [

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12599745 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature