Primary aldosteronism complicated by early-onset heart failure in a young male with a coexisting DMD variant: A case report and literature review.

ABSTRACT:

Rationale

Heart failure (HF) is slightly more common in primary aldosteronism (PA) than in essential hypertension, but early-onset HF remains rare. In such cases, underlying genetic cardiomyopathies should be considered. Autonomously secreted aldosterone and activation of the renin-angiotensin-aldosterone system can lead to extremely high aldosterone levels, worsening cardiac function and creating major therapeutic challenges.

Patient concerns

A 39-year-old male presented with progressive chest tightness and shortness of breath for 4 months. He had a 7-year history of hypertension and persistent hypokalemia. Electrocardiogram revealed a markedly reduced left ventricular ejection fraction of 18.3%.

Diagnosis and interventions

The patient was diagnosed with PA based on

SUBMITTER: Song X 

PROVIDER: S-EPMC12599770 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature