The association between maternal smoking and the risk of kidney diseases in offspring: A Mendelian randomization analysis based on large-scale GWAS.

ABSTRACT: Maternal smoking around birth (MSAB) has been associated with various adverse health outcomes in offspring, including an increased risk of kidney diseases. This study aims to investigate the potential causal relationship between MSAB and the risk of kidney diseases in descendants using Mendelian randomization (MR) methods, providing insights into the epidemiological background of kidney diseases and the application of MR in this context. We conducted a 2-sample MR analysis utilizing publicly available data from large-scale genome-wide association studies on MSAB (n = 397,732), breastfeeding (n = 352,094), and various kidney diseases, including acute kidney injury (AKI) (n = 482,266), chronic kidney injury (n = 482,858), glomerulonephritis (n = 500,348), renal malignancies (n = 463,010), an

SUBMITTER: Kang S 

PROVIDER: S-EPMC12599797 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature