Testing the effects of two different zebrafish exposure paradigms on transcriptomic-based chemical risk assessment using the flame retardant triphenyl phosphate.

ABSTRACT: In the zebrafish larval toxicity model, phenotypic changes induced by chemical exposure can potentially be explained and predicted by the analysis of gene expression changes at sub-phenotypic concentrations. The increase in knowledge of gene pathway-specific effects arising from the zebrafish transcriptomic model has the potential to enhance the role of the larval zebrafish as a component of Integrated Approaches to Testing and Assessment (IATA). In this paper, we compared the transcriptomic responses to triphenyl phosphate between 2 standard exposure paradigms, the Zebrafish Embryo Toxicity (ZET) and General and Behavioral Toxicity (GBT) assays. The ZET assay represents a developmental model with chemical exposure from 6 to 120 h post fertilization (hpf), which covers organogenesis, where

SUBMITTER: Morash MG 

PROVIDER: S-EPMC12599871 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature