Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol.

ABSTRACT:

Introduction

This retrospective open cohort study develops and externally validates a clinical prediction model (CPM) to predict the joint risk of two important outcomes occurring within the next year in people with epilepsy (PWE). These are: A) seizure-related emergency department or hospital admission; and B) epilepsy-related death. This will provide clinicians with a tool to predict either or both of these common outcomes. This has not previously been done despite both being potentially avoidable, interrelated, and devastating for patients and their families. We hypothesise that the CPM will identify individuals at high or low risk of either or both outcomes. We will guide clinicians on proposed actions to take based on the overall risk score.

Methods and analysis

Routine

SUBMITTER: Mbizvo GK 

PROVIDER: S-EPMC12599926 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature