Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.

ABSTRACT: In atrial fibrillation (AF), atrial biomechanics are altered, reducing atrial movement. It remains unclear whether these changes are due to altered anatomy, myocardial stiffness, or constraints from surrounding structures. Understanding the causes of changed atrial deformation in AF could enhance tissue characterization and inform AF diagnosis, stratification, and treatment. We created patient-specific anatomical models of the left atrium (LA) from CT images. Passive LA biomechanics were simulated using finite deformation continuum mechanics equations. LA stiffness was represented by the Guccione material law, where α scaled the anisotropic stiffness parameters. Regional passive stiffness parameters were calibrated to peak regional deformation during the reservoir phase and validated again

SUBMITTER: Baptiste TMG 

PROVIDER: S-EPMC12599961 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature