Surfactant proteins A and D nucleotide variants: association with retinal vascular disease.

ABSTRACT:

Background

Retinopathy of prematurity (ROP) is associated with systemic inflammation. Surfactant proteins A and D (SP-A and SP-D) play an immunomodulatory role. We previously reported the impact of SP-A on retinal angiogenesis. This study investigates SP-A and SP-D single-nucleotide polymorphisms (SNPs) with risk of ROP.

Methods

Subjects were infants with gestational age (GA) of <32 weeks and/or birth weight <1500 grams. DNA from blood was used to genotype the SNPs. Statistical analysis used logistic regression for the association of ROP with genetic and clinical factors, including bronchopulmonary dysplasia (BPD), GA, and oxygen exposure.

Results

A total of 59 infants were enrolled. In the whole cohort, the SFTPA1 SNP rs1059057 'G' allele was associated with increasi

SUBMITTER: Allen KB 

PROVIDER: S-EPMC12600029 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature