Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish.

ABSTRACT:

Background

Members of a class of bHLH transcription factors, namely the hairy (h), Enhancer of split (E(spl)) and hairy-related with YRPW motif (hey) (h/E(spl)/hey) genes are involved in vertebrate somitogenesis and some of them show cycling expression. By sequence comparison, identified orthologues of cycling somitogenesis genes from higher vertebrates do not show an appropriate expression pattern in zebrafish. The zebrafish genomic sequence is not available yet but the genome of Fugu rubripes was recently published. To allow comparative analysis, the currently known Her proteins from zebrafish were used to screen the genomic sequence database of Fugu rubripes.

Results

20 h/E(spl)/hey-related genes were identified in Fugu, which is twice the number of corresponding zebrafis

SUBMITTER: Gajewski M 

PROVIDER: S-EPMC126015 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature