Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas.

ABSTRACT:

Background

Melanoma affects skin and mucosa and can be particularly aggressive when the lesion is an advanced cutaneous tumor or located in the sinonasal or oral mucosa. Reprogramming of energy metabolism has been defined as a hallmark of cancer; so this study aimed to verify the expression of proteins related to metabolism and cellular proliferation.

Methods

Immunohistochemical analysis with antibodies adipophilin, FASN, GLUT-1, HIF-1α, and Ki-67 was performed in a series of 28 sinonasal melanomas (SM), 16 oral melanomas (OM), and 39 cutaneous melanomas (CM). For CM, 25 cases with matched lymph node metastases were analyzed, while 17 mucosal and 15 cutaneous melanocytic nevi served as controls.

Results

SM showed an increased frequency of undifferentiated cells, necro

SUBMITTER: de Souza do Nascimento J 

PROVIDER: S-EPMC12602135 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature