Diagnostic efficiency of inflammatory signatures to distinguish isolated candidemia from candidemia with bacterial co-infection.

ABSTRACT:

Introduction

To identify the differences in inflammatory response between critically ill patients responding to combined bacterial-fungal sepsis and those with isolated fungal sepsis.

Methods

A retrospective case-control study compared ICU patients who were exposed (n=24) and unexposed (n=20) to candidemia. Two exposure modes were analyzed: isolated candidemia (C; n=12) versus candidemia with bacterial co-infection (BC; n=12). Targeted proximity extension assay (PEA) was used to examine differences in serum inflammatory proteome between groups. Differential inflammatory proteins served as input for a logistic regression model to validate their effectiveness in discrimination.

Results

Two major clusters-candidemia cases and controls-were identified based on differentia

SUBMITTER: Mnichowska-Polanowska M 

PROVIDER: S-EPMC12602200 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature