Preconditioning donors with corticosteroids improves early lung graft immunity.

ABSTRACT:

Background

Preclinical studies have recently revealed the critical role of innate immunity in determining lung transplantation outcomes. Although the International Society for Heart and Lung Transplantation recommends high-dose corticosteroid administration to donors, this practice is inconsistently applied worldwide. Investigating its impact on the donor lung's innate immune response - an unexplored area - could provide valuable evidence to support adoption of donor preconditioning with corticosteroids, beyond their traditional administration to recipients.

Method

We used a cross-circulatory pig platform that consists of a donor lung placed extracorporeally and connected to the circulation of a recipient pig whose leukocytes are fluorescently labeled.

Results

Donor p

SUBMITTER: Schwartz-Cornil I 

PROVIDER: S-EPMC12602223 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature