Low level of serum total cholesterol predicts mortality in early-stage multiple system atrophy: a prospective-cohort study.

ABSTRACT:

Background

Serum total cholesterol (TC) is associated with the risk of multiple system atrophy (MSA). However, the potential impact of the serum TC levels on the mortality of patients with MSA remains to be elucidated. The study aims to clarify the association between baseline level of serum TC and survival of patients with early MSA.

Methods

A total of 364 patients with MSA were recruited and assessed at baseline and follow-up. Patients with MSA were stratified into three groups based on the serum TC tertiles. The role of serum TC on survival was analyzed using Kaplan-Meier survival analysis and Cox regression models. Restricted Cubic Spline regression was employed to investigate the non-linear relationship between serum TC levels and survival.

Results

During a media

SUBMITTER: Huang J 

PROVIDER: S-EPMC12602236 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature