Antibacterial Potential of Actinomycete Extracts and Characterization of β-Lactamase-Producing Multidrug-Resistant Uropathogenic Escherichia coli.

ABSTRACT: The increasing prevalence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) strains, particularly those producing β-lactamase enzymes, complicates urinary tract infection (UTI) treatment and poses a significant public health threat. This study investigates the antibacterial potential of actinomycete extracts against MDR UPEC isolates while characterizing their phylogenetic diversity and β-lactamase profiles. From 300 clinical UTI samples collected in Babil Province, Iraq, 50 UPEC isolates were confirmed via standard microbiological and biochemical assays. Phylogenetic analysis, utilizing PCR-based detection of chuA, yjaA, and TspE4.C2 loci, revealed that most isolates belonged to the virulent B2 group. Antibiotic susceptibility testing showed 64% of isolates were MDR, with

SUBMITTER: Khaledi H 

PROVIDER: S-EPMC12602258 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature