STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

ABSTRACT:

Background

Mitochondrial homeostasis is vital for optimal skeletal muscle integrity. Mitochondrial quality control (MQC) mechanisms that are essential for maintaining proper functions of mitochondria include mitochondrial biogenesis, dynamics and mitophagy. Previously, Syntaxin 4 (STX4), traditionally considered a cell surface protein known for glucose uptake in skeletal muscle, was also identified at the outer mitochondrial membrane. STX4 enrichment was sufficient to reverse Type 2 diabetes-associated mitochondrial damage in skeletal muscle by inactivation of mitochondrial fission. However, whether STX4 could modulate skeletal muscle mitochondrial homeostasis through MQC mechanisms involving mitochondrial biogenesis or mitophagy remains to be determined.

Methods

To determin

SUBMITTER: Hoolachan JM 

PROVIDER: S-EPMC12602274 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature