Comparative outcomes of middle meningeal artery embolization for chronic subdural hematoma: A comprehensive systematic review, meta-analysis, meta-regression and network meta-analysis.

ABSTRACT: BackgroundMiddle meningeal artery embolization (MMAE) has emerged as a promising minimally invasive approach for chronic subdural hematoma (cSDH). We aimed to compare the effectiveness of middle meningeal artery embolization (MMAE) as a standalone therapy, MMAE combined with surgery, and surgery alone, while also compare embolic agents (Onyx, NBCA, particles), and access approaches (femoral vs. radial).MethodsWe systematically searched PubMed, Scopus, and Web of Science through January 2025 for comparative studies focusing on MMAE and surgery in cSDH. Primary outcomes were recurrence and rescue surgery.ResultsA total of 44 studies (39 observational and 5 randomized controlled trials) met inclusion criteria. MMAE alone (OR: 0.39; CI: 0.25 to 0.64) and adjunctive MMAE (OR: 0.40; CI: 0.29 to

SUBMITTER: Musmar B 

PROVIDER: S-EPMC12602282 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature