Association between early-phase opioid use and outcomes in extremely preterm infants: A nationwide study.

ABSTRACT:

Background

Opioids are often administered for extremely preterm infants to prevent morbidities (e.g., intraventricular hemorrhage); however, their short-term outcome remains unclear. We aimed to assess the association between early-phase opioid use and in-hospital outcomes in extremely preterm infants.

Methods

This retrospective nationwide cohort study analyzed data from the Diagnosis Procedure Combination database in Japan. A total of 18,794 extremely preterm infants hospitalized between July 2010 and March 2021 were included. The patients were divided into those who received early-phase opioids (n = 4806) and those who did not (n = 13,988). We performed a 1:2 propensity score-matched analysis adjusting for patient backgrounds.

Results

In-hospital mortality, intraven

SUBMITTER: Kitaoka H 

PROVIDER: S-EPMC12602305 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature