Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization.

ABSTRACT: Brain imaging studies for attention-deficit/hyperactivity disorder (ADHD) have not always yielded consistent findings, potentially owing to measurement bias in magnetic resonance imaging (MRI) scanners. This study aimed to elucidate the structural brain characteristics in children with ADHD by addressing measurement bias in multi-site MRI data using the harmonization method, traveling-subject (TS) approach. The MRI data of 14 traveling subjects, 178 typically developing (TD) children, and 116 children with ADHD were collected from multiple sites. The TS method and ComBat were used to correct for measurement bias. Gray matter volumes were estimated using FreeSurfer, and the ADHD and TD groups were compared using mixed-effect models. Compared to raw data, the TS method significantly reduced

SUBMITTER: Shou Q 

PROVIDER: S-EPMC12602332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature