Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.

ABSTRACT:

Background

We examined the association between placental epigenetic gestational age (eGA) acceleration and adolescent systolic blood pressure (SBP) in a cohort born extremely preterm.

Methods

Study participants were a subset of the Extremely Low Gestational Age Newborn cohort (born <28 weeks' gestation) who had placental DNA methylation quantified and had SBP measured during adolescent follow-up. eGA acceleration was calculated as the residual from the regression of predicted placental eGA (using the Robust Placental Clock) onto chronological gestational age. Unadjusted and adjusted mixed effects models were used to test the association between eGA acceleration and adolescent SBP. We also tested the interaction of eGA acceleration and sex on SBP.

Results

In the overal

SUBMITTER: Gerber A 

PROVIDER: S-EPMC12602336 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature