Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits.

ABSTRACT: There is an elevated risk of depression and anxiety in offspring of parents with a history of these disorders. Beyond direct transmission, parental genes may also impact offspring outcomes through the environment, in a "genetic nurture" pathway. The scarcity of relevant data has limited studies in this area, resulting in an incomplete understanding of the indirect impact of parental genes on the familial transmission of depression and anxiety. We investigated genetic nurture effects in 15,231-17,186 Dutch adults with at least one genotyped parent from Lifelines, a large general population cohort. We computed polygenic scores for transmitted (PGS-T) and non-transmitted (PGS-NT) parental haplotypes using genome-wide association studies for depression. Using mixed-effect regression models, we

SUBMITTER: Trindade Pons V 

PROVIDER: S-EPMC12602338 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature