Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex.

ABSTRACT: Emerging evidence suggests that a single bout of physical exercise can induce rapid antidepressant effects, yet the underlying neural mechanisms remain largely unknown. We established a mouse model designed to mimic the mood-elevating effects of acute exercise observed in humans. We found that this rapid antidepressant response in exercised mice correlated with increased brain levels of adiponectin, an adipocyte-secreted hormone. Using whole-brain c-Fos mapping, immunofluorescence staining of glutamatergic neurons using the marker CaMKII, and in vivo calcium imaging, we identified ACC glutamatergic neurons that were rapidly activated by single-bout physical exercise. Chemogenetic manipulation of these neurons modulated the rapid antidepressant effects of exercise. Genetic manipulations dem

SUBMITTER: Cheng T 

PROVIDER: S-EPMC12602346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature