Heterogeneity in Kawasaki disease patients with coronary artery abnormalities investigated by data-driven cluster analysis.

ABSTRACT:

Background

To clarify the clinical characteristics associated with coronary artery abnormality (CAA) in the acute phase of Kawasaki disease (KD) cases, we performed a cluster analysis.

Methods

A retrospective cohort study of 103 KD cases that developed CAA (maximum Z-score for any coronary arteries >2.5) within 30 days after disease onset was conducted among 726 consecutive KD cases. The hierarchical cluster analysis was performed based on 20 continuous variables before treatment.

Results

101 out of 103 cases were clustered into 4 subgroups. Cluster 1 was a younger group characterized by leukocytosis and elevated serum triglyceride levels with frequent coronary artery dilation before treatment and good initial treatment responses. Cluster 2 was a younger group charact

SUBMITTER: Sunaga Y 

PROVIDER: S-EPMC12602351 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature