Functional brain connectivity in early adolescence after hypothermia-treated neonatal hypoxic-ischemic encephalopathy.

ABSTRACT:

Background

Neonatal hypoxic-ischemic encephalopathy (HIE) injures the infant brain during the basic formation of the developing functional connectome. This study aimed to investigate long-term changes in the functional connectivity (FC) networks of the adolescent brain following neonatal HIE treated with therapeutic hypothermia (TH).

Methods

This prospective, population-based cohort study included all infants (n = 66) with TH-treated neonatal HIE in Stockholm during 2007-2009 and a control group (n = 43) of children with normal neonatal course. Assessment with resting-state functional magnetic resonance imaging (fMRI) was performed at Karolinska Institutet, Stockholm at age 9-12 years.

Results

fMRI data met quality criteria for 35 children in the HIE-cohort (mean [SD]

SUBMITTER: Hakansson G 

PROVIDER: S-EPMC12602361 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature