Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients.

ABSTRACT: Metabolic alterations have been observed in the brains of patients with bipolar disorder (BD), a neuropsychiatric disorder characterized by alternating episodes of mania and depression. However, the specific contributions of glial cells to these metabolic changes remain largely unknown. Here, we investigate the metabolic characteristics of induced astrocytes (iAstrocytes) derived from induced pluripotent stem cells of BD patients-classified by lithium responsiveness-and healthy controls. Transcriptomic analyses revealed dysregulated expression of genes associated with metabolic diseases in BD iAstrocytes. Compared to control iAstrocytes, BD iAstrocytes showed decreased mitochondrial respiration, increased glycolysis, and elevated lactate secretion, indicating impaired mitochondrial functio

SUBMITTER: Baek GH 

PROVIDER: S-EPMC12602366 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature