Melorheostosis: Clinical, radiological, and histopathological features with a literature review.

ABSTRACT: Melorheostosis is a rare sclerosing bone dysplasia that can clinically and radiologically mimic common bone disorders, particularly in atypical presentations. Its heterogeneous manifestations and limited awareness among clinicians frequently contribute to diagnostic delays or misdiagnosis. We report the case of a 34-year-old woman with chronic forearm pain and a longstanding subcutaneous mass. She was initially misdiagnosed as having a metabolic bone disorder based on imaging and histopathology. However, subsequent evaluation with MRI and bone scintigraphy demonstrated eccentric cortical thickening and longitudinal sclerotic lesions involving the radius, olecranon, and first metacarpal. Normal biochemical markers and the absence of systemic involvement further supported a diagnosis of melo

SUBMITTER: Koca E 

PROVIDER: S-EPMC12602463 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature