An oral M-cell targeted <i>Lactococcus lactis</i> vaccine against <i>Echinococcus multilocularis</i> infection.

ABSTRACT:

Background

Alveolar Echinococcosis (AE) is a serious infectious disease caused by Echinococcus multilocularis (E.multilocularis,Em) in the highlands of northwestern China and vaccination is currently the most effective means of preventing E. multilocularis infection. However, current vaccines are not sufficiently effective in preventing and controlling Alveolar Echinococcosis.

Methods

In this study, an oral M-cell targeted Lactococcus lactis (L. lactis) vaccine (LL-plSAM-GILE) was constructed by adding SAM gene sequence to the epitope vaccine GILE for E. multilocularis constructed in our previous study. Mice were orally immunized with LL-plSAM-GILE and their serum antibody levels (ELISA), lymphocyte proliferation (MTS), IFN-γ levels (ELISpo

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12602529 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature