The Causal Relationship Between Zinc and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

ABSTRACT: There is a clear relationship between osteoarthritis (OA) and micronutrients. Excessive accumulation of micronutrients may play a negative role in aggravating the symptoms of OA. This study aims to sort out the causal relationship between micronutrients (zinc, copper, magnesium, vitamins A, C, E, D, B6, and B12, folic acid, iron, carotene, selenium, calcium, and potassium) and OA. This study used Mendelian randomization (MR) to combining the causal relationship between micronutrients and the risk of OA. Micronutrient-related variants were extracted from a large-scale genome-wide association study (GWAS) database of circulating micronutrients in European populations. Outcome data were from the FINNGEN meta-analysis of OA in participants of European ancestry from the FinnGen Biobank in Finla

SUBMITTER: Gao T 

PROVIDER: S-EPMC12602555 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature