Time trends and health inequalities of cirrhosis caused by metabolic Dysfunction-associated steatotic liver disease from 1990 to 2021: A global burden of disease study.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD)-related cirrhosis has become an important global public health concern, particularly in certain vulnerable populations, with its incidence continuing to rise. This study aims to systematically analyze the epidemiological trends of MASLD-related cirrhosis and predict future incidence rates. The findings will provide critical scientific evidence to inform effective prevention and intervention strategies to address the public health challenges posed by this disease.

Methods

The burden of MASLD-related cirrhosis globally, regionally, and by country was analyzed from 1990 to 2021, stratified by age, sex, and socio-demographic index. Age-period-cohort (APC) models were used to analyze trends in different a

SUBMITTER: Wu M 

PROVIDER: S-EPMC12602580 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature